New Advances in Atroposelective Synthesis of Axial Chirality via Asymmetric Gold(I)-Catalyzed Annulation of Diazo-Alkynes

Yi-Bo Wang; Nie Xin; Li Long

doi:10.1055/a-2701-6151

Synlett, Table of Contents

Synlett
DOI: 10.1055/a-2701-6151

Synpacts

New Advances in Atroposelective Synthesis of Axial Chirality via Asymmetric Gold(I)-Catalyzed Annulation of Diazo-Alkynes

Authors

Yi-Bo Wang

¹College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, China (Ringgold ID: RIN26495)
Nie Xin

²College of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing, China (Ringgold ID: RIN372299)
Li Long

¹College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, China (Ringgold ID: RIN26495)

Abstract

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Abstract

Atropisomeric architectures, now as a characteristic of valuable chiral ligands and organocatalysts, are increasingly encountered in modern materials and pharmacy. More importantly, the Au-catalyzed diazo-alkyne carbocyclization has become a flexible tool for facile construction of carbocyclic compounds, yet the preparation of axial chirality via asymmetric gold-catalyzed intermolecular alkyne transformations is scarcely reported. This mini-review aims to summarize the latest development of the axial atroposelective synthesis via Au-catalyzed annulation of diazo-alkyne.

Keywords

Gold catalysis - Diazo-alkynes - Atroposelectivity - Annulation - Co-catalysis

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References

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